CSF antiretroviral drug penetrance and the treatment of HIV-associated psychomotor slowing

The authors evaluated whether highly active antiretroviral therapy (HAART) with multiple CSF-penetrating drugs results in greater improvement in HIV-a ssociated psychomotor slowing than HAART with a single CSF-penetrating drug . Both groups had improvement in CD4 count, plasma viral load, as well as t wo tests of psychomotor speed. Comparing the two groups, there were no diff erences in the mean change for CD4 count, viral load, or any of the neurops ychological tests. Multiple and single CSF-penetrating HAART may be equival ent for treating HIV-associated psychomotor slowing.