Abolished angiogenicity and tumorigenicity of rat glioma by 1-naphthalenemonosulfonate

Suramins and suradistas, an important group of potential anti-cancer agents , inhibit fibroblast growth factor (FGF) mitogenic activity. It has been sh own that naphthalenesulfonates, with a common chemical function to the fami ly of suramins and suradistas, mimic their inhibitory activity, abolishing FGF-induced angiogenesis in vivo, and inducing apoptosis of C6 glioma cells in culture. In the present report, we show that intratumoral administratio n of 1-naphthalenemonosulfonate induces a considerable regression of glioma s in rats, significantly enhances apoptosis, and attenuates tumor angiogene sis. These findings may lead to new approaches for the treatment of gliobla stoma, a most common primary malignant brain tumor of very poor prognosis, as well as of other angiogenesis-dependent malignancies. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.