Preparation of 2,5-disubstituted oxazoles from N-propargylamides

Authors
Arcadi, A Cacchi, S Cascia, L Fabrizi, G Marinelli, F
Citation
A. Arcadi et al., Preparation of 2,5-disubstituted oxazoles from N-propargylamides, ORG LETT, 3(16), 2001, pp. 2501-2504
Citations number
40
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
16
Year of publication
2001
Pages
2501 - 2504
Database
ISI
SICI code
1523-7060(20010809)3:16<2501:PO2OFN>2.0.ZU;2-I
Abstract
[GRAPHICS] 2,5-Disubstituted oxazoles have been prepared through the reaction of N-pro pargylamides with aryl iodides in the presence of Pd-2(dba)(3), tri(2-furyl )phosphine, and (NaOBu)-Bu-f. The reaction appears to proceed through a pal ladium-catalyzed coupling step followed by the in situ cyclization of the r esultant coupling product.