Limited information is available about the pathogenesis and pathophysiology
of oedema disease (OD). Oedema disease is caused by specific enterotoxemic
Escherichia coli (SLTIIv-toxin producing) strains: however, the same strai
ns are also found in non-afflicted pigs. Furthermore. it is unclear how the
80 kDa SLTIIv-toxin can pass the intestinal barrier.
In the present paper. piglets showing signs of acute OD were anaesthetised.
instrumented and cardiovascular and intestinal parameters were determined
at 0, 1, 2 and 3 hours. Healthy piglets from the same herd were used as a c
ontrol.
Cardiac output, blood pH and bicarbonate, small intestinal intramucosal pH,
and (pulmonary) blood pressure were significantly lower in OD-pigs than in
control pigs. It is concluded that OD is associated with metabolic and int
estinal acidosis. Intestinal acidosis is known to increase macromolecular p
ermeability. This suggests that once OD has developed, influx of SLTIIv-tox
in into the blood stream is facilitated. thus perpetuating the disease. Sin
ce intestinal permeability appears to be central in OD, it is argued that p
ost-weaning events increase intestinal permeability and predispose individu
als to OD. (C) 2001 Harcourt Publishers Ltd.