Sarcoidosis and associated illnesses. A 32-case retrospective study

Citation
F. Bonnet et al., Sarcoidosis and associated illnesses. A 32-case retrospective study, REV MED IN, 22(7), 2001, pp. 619-623
Citations number
25
Categorie Soggetti
General & Internal Medicine
Journal title
REVUE DE MEDECINE INTERNE
ISSN journal
02488663 → ACNP
Volume
22
Issue
7
Year of publication
2001
Pages
619 - 623
Database
ISI
SICI code
0248-8663(200107)22:7<619:SAAIA3>2.0.ZU;2-2
Abstract
Purpose. - A retrospective study was set up to investigate active pathologi c processes associated with sarcoidosis diagnosed in 32 patients. Methods. - Eighteen patients had two identified granulomatous localizations (569%) and 14 patients had three localizations or more (27%). Comorbidity was noticed in nine patients (28% of cases). Sarcoidosis was associated wit h an Infectious disease five times (hepatitis C virus [HCV] infection three times, including one case after recombinant interferon alpha therapy, and HIV and HCV co-infection two times). The association of sarcoidosis with a chronic immunologic inflammatory disease was noticed four times (lupus eryt hematosus two times, myasthenia and primary biliary cirrhosis). Finally, in two cases sarcoidosis was associated with a neoplasia (non-Hodgkin's lymph oma in a co-infected HIV-HCV patient, ovarian cystadenocarcinoma in another patient). Sarcoidosis preceded or revealed the comorbidity four times. Conclusion. - Prospective studies should allow the finding of significant p athologic processes associated with sarcoidosis and to progress in the iden tification of its triggering factors; they should also help to define the r elevant etiologic research to practice when faced with this granulomatosus. (C) 2001 Editions scientifiques et medicales Elsevier SAS.