We describe herein an extremely unusual case of a gastrointestinal stromal
tumor (GIST) of the lesser omentum. A 45-year-old man was admitted to our h
ospital with an intra-abdominal mass that was subsequently misdiagnosed as
a submucosal tumor of the stomach. The tumor arose from the lesser omentum
and was removed without difficulty. Histologically, the tumor was composed
of spindle-shaped cells with an interlacing bundle pattern, and immunohisto
chemical examination showed that it was positive for myeloid stem cell anti
gen (CD34), but negative for HHF35 and S-100 protein. These findings were c
onsistent with a GIST lacking myogenic features and neural attributes. The
patient had an uneventful postoperative course, and was free of recurrence
when last seen 11 months after his operation.