Studies on 6-[(Dimethylamino)methylene]aminouracils: a facile one-pot synthesis of pyrimido[4,5-d]pyrimidines and pyrido[2,3-d]pyrimidines.

Authors
Thakur, AJ Saikia, P Prajapati, D Sandhu, JS
Citation
Aj. Thakur et al., Studies on 6-[(Dimethylamino)methylene]aminouracils: a facile one-pot synthesis of pyrimido[4,5-d]pyrimidines and pyrido[2,3-d]pyrimidines., SYNLETT, (8), 2001, pp. 1299-1301
Citations number
30
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
8
Year of publication
2001
Pages
1299 - 1301
Database
ISI
SICI code
0936-5214(200108):8<1299:SO6AFO>2.0.ZU;2-8
Abstract
6-[(Dimethylamino)methylene] amino-1,3-dimethyl uracil 1 undergoes formal [ 4+2] cycloaddition reaction with non conjugated imines to give pyrimido[4,5 -d]pyrimidines 3. When reacted with conjugated imines and alpha,beta -unsat urated nitro compounds cycloaddition also occurs leading to unexpected pyri do[2.3-d]pyrimidines 5 and 9, respectively.