Novel syntheses of densely functionalized indolizines, di- and tetrahydroindolizines from 2-formyl-1,4-dihydropyridine systems based on cascade process

Authors
Marchalin, T Cvopova, K Pham-Huu, DP Chudik, M Kozisek, J Svoboda, I Daich, A
Citation
T. Marchalin et al., Novel syntheses of densely functionalized indolizines, di- and tetrahydroindolizines from 2-formyl-1,4-dihydropyridine systems based on cascade process, TETRAHEDR L, 42(33), 2001, pp. 5663-5667
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
33
Year of publication
2001
Pages
5663 - 5667
Database
ISI
SICI code
0040-4039(20010813)42:33<5663:NSODFI>2.0.ZU;2-G
Abstract
Several indolizines, di- and tetrahydroindolizines have been synthesized su ccessfully in a one-pot procedure, in two or three steps from 2-formyl-1,4- dihydropyridine derivatives and malonitrile in 57-87%,, yield. The general mechanism leading to these azacyclic compounds, involving 2-dicyanovinyl-1, 4-dihydropyridines, is discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.