Preparation of polyfunctional pyridines by a palladium(-0)-catalyzed cross-coupling of functionalized aryl Grignard reagents

Authors
Bonnet, W Mongin, F Trecourt, F Queguiner, G Knochel, P
Citation
W. Bonnet et al., Preparation of polyfunctional pyridines by a palladium(-0)-catalyzed cross-coupling of functionalized aryl Grignard reagents, TETRAHEDR L, 42(33), 2001, pp. 5717-5719
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
33
Year of publication
2001
Pages
5717 - 5719
Database
ISI
SICI code
0040-4039(20010813)42:33<5717:POPPBA>2.0.ZU;2-R
Abstract
Difunctionalized pyridines can be prepared by a Pd(0)-catalyzed cross-coupl ing of functionalized arylmagnesium compounds with chloro- or bromopyridine s at temperatures as low as -40 degreesC. An addition elimination mechanism involving a palladate intermediate is proposed. (C) 2001 Elsevier Science Ltd. All rights reserved.