Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone

Authors
Tsai, FY Lin, SB Tsay, SC Lin, WC Hsieh, CL Chuang, SH Kan, LS Hwu, JR
Citation
Fy. Tsai et al., Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone, TETRAHEDR L, 42(33), 2001, pp. 5733-5735
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
33
Year of publication
2001
Pages
5733 - 5735
Database
ISI
SICI code
0040-4039(20010813)42:33<5733:PCOSAD>2.0.ZU;2-8
Abstract
Irradiation, with 350 nm UV light, of specially designed and synthesized si ngle- and double-stranded oligodeoxyribonucleotides in the presence of 3-(p -tolylamino)-1,5-azulenequinone produced fragments resulting from the cleav age at the deoxyguanosine residue only. The cleaving efficiency was greater for a single strand than a double helix. The efficiency was increased for a less stable double helix. or while the deoxyguanosine residue therein was located at a bulge. at a hairpin loop, or towards the end of the helix. (C ) 2001 Elsevier Science Ltd. All rights reserved.