Post-translational protein modifications in antigen recognition and autoimmunity

Citation
Ha. Doyle et Mj. Mamula, Post-translational protein modifications in antigen recognition and autoimmunity, TRENDS IMMU, 22(8), 2001, pp. 443-449
Citations number
61
Categorie Soggetti
Immunology
Journal title
TRENDS IN IMMUNOLOGY
ISSN journal
14714906 → ACNP
Volume
22
Issue
8
Year of publication
2001
Pages
443 - 449
Database
ISI
SICI code
1471-4906(200108)22:8<443:PPMIAR>2.0.ZU;2-H
Abstract
It is estimated that 50-90% of the proteins in the human body are posttrans lationally modified. In the proper context, these modifications are necessa ry for the biological functions of a vast array of proteins and the effecto r functions of the cells in which they reside. However, it is now clear tha t some post-translational modifications can create new self antigens (Ags) or even mask Ags normally recognized by the immune system. In either case,t hey profoundly affect the recognition of Ag by bone marrow-derived cells, a s well as their effector functions. How do post-translational protein modif ications affect the processing of foreign and self Ags and what is their ro le in the origin of autoimmune responses?