J. Jordan et al., MODERATE EXERCISE LEADS TO DECREASED EXPRESSION OF BETA-1 AND BETA-2 INTEGRINS ON LEUKOCYTES, European journal of applied physiology and occupational physiology, 76(2), 1997, pp. 192-194
Intravascular adhesion of leucocytes plays a role in the pathogenesis
of acute and chronic vascular disease. Regular aerobic exercise seems
to protect against vascular disease. Since leucocyte adhesion is media
ted by integrins, we tested the hypothesis that surface expression of
the integrin adhesive receptors LFA-1 (cd11a/cd18), MAC-1 (cd11b/cd18)
. gp 150/95 (cd11c.cd18), and VLA-4 (cd29/cd49) is decreased by modera
te endurance exercise, Surface expression of integrins was measured by
FAGS analysis in 19 healthy subjects (16 males, 3 females, 36.6 +/- 8
.7 years, 177.1 +/- 7.5 cm, 70.3 +/- 8.1 kg) before and after sub-maxi
mal exercise (3 h run) using monoclonal antibodies against cd11a, cd11
b, cd11c, cd18, cd29 and cd49. In addition, wee compared resting integ
rin expression in this group with a group of sedentary subjects (19 ma
les, 6 females, 29.3 +/- 5.3 years), White blood cell count increased
from 5300 ml(-1) to 9740 ml(-1) during exercise (P<0.001), Nevertheles
s, the expression (indicated by the mean log fluorescence) of cd11a (9
4 +/- 24 vs. 78 +/- 14) and cd18 (128 +/- 31 vs, 102 +/- 21) on lympho
cytes and of cd11a (104 +/- 25 vs, 85 +/- 16), cd11c (497 +/- 171 vs,
408 +/- 126) cd29 (109 +/- 16 vs, 89 +/- 16), cd49 (69 +/- 8 vs, 54 +/
- 11) on monocytes was decreased after exercise (all P<0.05). In contr
ast, integrin expression on granulocytes was not altered by exercise,
Comparison of exercising and sedentary subjects showed a significantly
decreased expression bf integrins in exercising subjects, Our results
demonstrate that moderate exercise leads to decreased expression of i
ntegrin receptors on leucocytes. This decreased expression of adhesion
molecules may result in decreased adhesion and infiltration of leucoc
ytes into the vessel wall. This phenomenon may play a role in the bene
ficial effect of moderate exercise in prevention of acute and chronic
vascular disease.