Objectives. To determine the consistency of a successful response to intrau
rethral prostaglandin El (MUSE), an effective treatment for a proportion of
patients with erectile dysfunction, during at-home use in men who had a su
ccessful response in the office, to define the factors that correlated with
the consistency of the response, and to determine whether patients continu
ed long-term use.
Methods. The study group consisted of men with documented erectile dysfunct
ion who had a successful response (grade 3 or 4 erection) to MUSE during an
initial in-office dose. All enrollees completed a home diary assessing the
treatment success during at least five medication administrations. Factors
such as patient age, vascular risk factor status, and degree of in-office
response were prospectively evaluated as correlates of response consistency
. Finally, patient follow-up was conducted in an attempt to define how many
patients were continuing to use this medication as a long-term treatment m
odality.
Results. Two hundred twelve patients underwent screening and 72 (34%) patie
nts had in-office success. The overall per patient at-home consistency rate
was 51%. None of the aforementioned factors correlated with the consistenc
y of the response, At a mean of 9 months after beginning treatment, only 31
% of the in-off ice responders were continuing to use MUSE.
Conclusions. Although MUSE is an appropriate and safe treatment for many pa
tients with erectile dysfunction, the lack of consistency is a significant
consideration. Clinicians should pay close attention to patient education i
n an effort to promote realistic expectations for MUSE therapy. Furthermore
, the lack of consistency may significantly lower the patient's interest in
continuing this treatment long term. UROLOGY 58: 262-266, 2001. (C) 2001,
Elsevier Science Inc.