Pancreatectomy combined with superior mesenteric-portal vein resection foradenocarcinoma in pancreas

The aims of this study were to investigate morbidity, mortality, and surviv al of patients with ductal adenocarcinoma of the pancreas who underwent pan createctomy without (group 1) or with (group 2) en bloc portal vein resecti on and to study the degree of carcinoma invasion of the portal vein in grou p 2. The medical records of 46 and 28 patients in groups I and 2, respectiv ely, were reviewed. In addition, the degree of invasion of the wall of the portal vein was categorized histologically into three types: type 1, transm ural invasion involving the intima; type II, invasion of the wall of the ve in without intimal involvement; and type III, compression of the wall of th e vein by surrounding carcinoma without true invasion. The morbidity and mo rtality in group 1 (26% and 4%) were not different from those in group 2 (3 2% and 4%). Similarly, there was no difference in survival between the two groups. Survival tended to vary directly with the depth of invasion of the wall of the portal vein: type 1 6.8 +/- 1.9 months; type II 15.3 +/- 6.4 mo nths; type III 20.6 +/- 13.0 months. These findings suggest that en bloc re section of the pancreas and the portal vein does not increase mortality and morbidity after pancreatectomy; survival after en bloc resection was simil ar to that of patients not requiring portal vein resection. Combined resect ion of the pancreas with the portal vein could be an option in the treatmen t of pancreatic cancer with direct invasion of the portal vein.