The majority of adult brachial plexus palsies are posttraumatic injuries ca
used by high-energy forces, usually involving motor vehicles. In infants, b
rachial plexus palsies commonly represent obstetrical injuries following ex
cessive traction on the plexus during complex or difficult delivery. Most a
dult injuries, and occasionally those in infants, represent brachial plexus
root avulsion injuries that carry serious ramifications from the standpoin
t of permanent disability of a paralyzed extremity, prolonged recuperation,
and significant socioeconomic impact. Modern-day management of root avulsi
ons should focus on early, aggressive microsurgical reconstruction of the b
rachial plexus, combining various neurotizations with intraplexus and extra
plexus ipsilateral and contralateral nerve donors, utilization of vasculari
zed nerve grafts, and finally the use of free vascularized and neurotized m
uscles. When these multistage microsurgical management techniques are appli
ed early (with complete avulsions) they may often result in significant ret
urn of neurologic function, especially in young patients. Amputation should
be looked upon as an option only when these newer microsurgery techniques
have failed.