Cf. Moreno-luque et al., Properties of the magnesium(II) and calcium(II) complexes of 5- and 6-uracilmethylphosphonate (5Umpa(2-) and 6Umpa(2-)) aqueous solution, Z ANORG A C, 627(8), 2001, pp. 1882-1887
Citations number
18
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
The stability constants of the 1:1 complexes formed between Mg2+ or Ca2+ an
d 5 Umpa(2-) or 6 Umpa(2-) were determined by potentiometric pH titrations
in aqueous solution (25 degreesC. I = 0.1 M, NaNO3). Based on previously es
tablished log K-M(R-PO3)(M) versus pK(H(R-PO3))(H) straight-line plots (M2 = Mg2+ or Ca2+; R-PO32- = simple phosphate monoester or phosphonate ligand
s where R is a non-interacting residue), it is shown that the Mg(5 Umpa), C
a(5 Umpa), Mg(6 Umpa) and Ca(6 Umpa) complexes have the stability expected
on the basis of the basicity of the phosphonate group in 5 Umpa(2-) and 6 U
mpa(2-). This means, these Ligands may be considered as simple analogues of
nucleotides, e.g. of uridine 5 ' -monophosphate. In the higher pH range de
protonation of the uracil residue in the M(5 Umpa) and M(6 Umpa) complexes
occurs and this leads to the negatively charged M(5 Umpa-H)(-) and M(6 Umpa
-H)(-) species. Based on the comparison of various acidity constants it is
shown that the M(5 Umpa) complexes are especially acidic; or to say it diff
erently, the M(5 Umpa-H)(-) species are especially stable. This increased s
tability is attributed to the formation of a seven-membered chelate involvi
ng next to the phosphonate group also the carbonyl oxygen atom at C4 (after
deprotonation of the (N3)H site). The formation degree of this chelated is
omer reaches about 45% for the Mg(5 Umpa-H)(-) and Ca(5 Umpa-H)(-) species.
No indication for chelate formation was observed for the M(6 Umpa-H)(-) co
mplexes.