Severe hepatotoxicity with jaundice associated with paroxetine

Hepatotoxicity due to paroxetine, a selective serotonin reuptake inhibitor, is very rare, and to the best of our knowledge, only five cases of liver i njury in association with paroxetine have previously been reported in the m edical literature. We describe the clinical, biochemical, and pathological findings in a patient with paroxetine hepatotoxicity, which was reversed af ter withdrawal of the drug. The present case and the others previously repo rted suggest that hepatotoxicity should be taken into account as a rare com plication. sometimes severe, that may occur with paroxetine.