Epilepsy is a common occurrence in persons with mental retardation. Th
e application of recent advances in epilepsy research to patients with
mental retardation has shown that well-accepted principles of managem
ent are as relevant for multiply handicapped people as for those with
epilepsy alone. Quality enhancement is emphasized as the overarching c
oncept that determines the quality of care provided to patients with e
pilepsy and mental retardation. This article reviews the comprehensive
management of epilepsy, discusses what is known at present, and indic
ates what is not known and needs further research.