Jk. Lee et al., Comparison of cyfra 21-1 and squamous cell carcinoma antigen in detecting nasopharyngeal carcinoma, ANN OTOL RH, 110(8), 2001, pp. 775-778
CYFRA 21-1 is a newly developed tumor marker that is especially useful for
detecting squamous cell carcinoma (SCC) of the lung. Squamous cell carcinom
a antigen is a proven tumor marker that is especially useful for detecting
SCC of the cervix. Our aim in this study was to compare the clinical value
of CYFRA 21-1 and SCC antigen in the detection of nasopharyngeal carcinoma
(NPC). Serum levels of CYFRA 21-1 and SCC antigen were measured in 80 untre
ated NPC patients and 77 healthy controls. The cutoff values of CYFRA 21-1
and SCC antigen, determined at the 95th percentile of the 77 healthy contro
ls, were 2.48 ng/mL and 1.49 ng/mL, respectively. The results revealed that
the mean serum value of only CYFRA 21-1 was significantly higher in the 80
NPC patients than in the 77 healthy controls, and the detection sensitivit
y of CYFRA 21-1 for NPC was significantly higher than that of SCC antigen.
In conclusion, our results suggest that CYFRA 21-1 is a better tumor marker
than SCC antigen for detection of NPC.