Recently, several studies have emphasized the role of R&D expenditure in de
termining Total Factor Productivity (TFP). In this paper it is shown that t
he relationship between R&D variables and TFP is far from being established
. In particular, by using data for the Italian economy, it is found that th
e estimated effects of R&D variables on TFP crucially depends on: (i) the w
ay in which the production function, used to derive Solow residuals, is def
ined; (ii) the numbers of maintained hypotheses used to estimate Solow resi
duals; (iii) the level of aggregation of the data employed in the empirical
analysis.