Regional lymph node dissection in the treatment of renal cell carcinoma: is it useful in patients with no suspected adenopathy before or during surgery?

Objectives To evaluate the role of regional lymph node dissection (LND) in a series of patients with renal cell carcinoma (RCC) with no suspicion of n odal metastases before or during surgery. Patients and methods A series of 167 patients with RCC, free from distant m etastases at diagnosis, and who underwent radical nephrectomy at our hospit al between January 1990 and October 1997, was reviewed. The mean (median. r ange) follow-up was 51 (45, 19-112) months. Of the 167 patients, 108 underw ent radical nephrectomy alone and 59 had radical nephrectomy with regional LND limited to the anterior, posterior and lateral sides of the ipsilateral great vessel, from the level of the renal pedicle to the inferior mesenter ic artery. Of these 59 patients, 49 had no evidence of nodal metastases bef ore or during surgery. The probability of survival was estimated by the Kap lan-Meier method, using the log-rank test to estimate differences among lev els of the analysed variables. Results The overall 5-year survival was 79%; the 5-year survival rate for t he 108 patients who underwent radical nephrectomy alone was 79% and for the 49 who underwent LND was 78%. Of the 49 patients with no suspicion of lymp h node metastases, one (2%) was found to have histologically confirmed posi tive nodes. Conclusion These results suggest that there is no clinical benefit in terms of overall outcome in undertaking regional LND in the absence of enlarged nodes detected before or during surgery.