The 2-year symptomatic and urodynamic results of a prospective randomized trial of interstitial radiofrequency therapy vs transurethral resection of the prostate
Rg. Hindley et al., The 2-year symptomatic and urodynamic results of a prospective randomized trial of interstitial radiofrequency therapy vs transurethral resection of the prostate, BJU INT, 88(3), 2001, pp. 217-220
Objective To assess the 2-year symptomatic and Urodynamic results of a pros
pective randomized trial of interstitial radiofrequency therapy of the pros
tate (IRFT) vs transurethral resection of the prostate (TURP).
Patients and methods Patients with lower urinary tract symptoms (LUTS) and
Urodynamic evidence of bladder outlet obstruction (BOO) were randomized to
undergo IRFT or TURP and were followed up using the International Prostate
Symptom Score (IPSS) and urodynamic assessment for 2 years.
Results At 2 years there was a clinically relevant reduction in the IPSS in
the IRFT (20 to 9) and TURP groups (22 to 4). There was also a statistical
ly significant reduction in the detrusor pressure at maximum urinary flow i
n both groups, but the reduction in the IRFT group was probably not suffici
ent to explain the observed symptomatic improvements solely from it reducti
on in BOO.
Conclusion IRFT can produce a sustained improvement in LUTS for at least 2
years. However, such improvements arc unlikely to be entirely the result of
a reduction in BOO. The effects of radiofrequency energy may. at least par
tly, be independent of any thermal effect and depend instead on neuromodula
tion of lower urinary tract nerves.