A pharmacoeconomic analysis of the impact of therapeutic drug monitoring in adult patients with generalized tonic-clonic epilepsy

Citation
Ct. Rane et al., A pharmacoeconomic analysis of the impact of therapeutic drug monitoring in adult patients with generalized tonic-clonic epilepsy, BR J CL PH, 52(2), 2001, pp. 193-195
Citations number
6
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
ISSN journal
03065251 → ACNP
Volume
52
Issue
2
Year of publication
2001
Pages
193 - 195
Database
ISI
SICI code
0306-5251(200108)52:2<193:APAOTI>2.0.ZU;2-9
Abstract
Aims To carry out a retrospective pharmacoeconomic analysis of the impact o f therapeutic drug monitoring (TDM) in adult patients with generalized toni c-clonic epilepsy in an academic, non profit making organization. Methods Twenty-five patients who had undergone TDM were compared with 25 ag e, disease and duration of drug therapy matched controls who had not underg one TDM. Only direct costs were calculated. These included cost to the hosp ital of providing the TDM service, cost to the hospital per seizure saved, and cost to the patient per seizure saved. Results Patients undergoing TDM had much more effective seizure control (P = 0.00032, OR 4.846, 95% confidence interval 1.29,18.3), fewer adverse even ts, better earning and were more likely to be married than the control grou p. Conclusions In patients with adult onset epilepsy, a minimum of two drug es timations per year offers significant benefit in terms of better seizure co ntrol, fewer adverse events and greater chances of remission.