Ct. Rane et al., A pharmacoeconomic analysis of the impact of therapeutic drug monitoring in adult patients with generalized tonic-clonic epilepsy, BR J CL PH, 52(2), 2001, pp. 193-195
Aims To carry out a retrospective pharmacoeconomic analysis of the impact o
f therapeutic drug monitoring (TDM) in adult patients with generalized toni
c-clonic epilepsy in an academic, non profit making organization.
Methods Twenty-five patients who had undergone TDM were compared with 25 ag
e, disease and duration of drug therapy matched controls who had not underg
one TDM. Only direct costs were calculated. These included cost to the hosp
ital of providing the TDM service, cost to the hospital per seizure saved,
and cost to the patient per seizure saved.
Results Patients undergoing TDM had much more effective seizure control (P
= 0.00032, OR 4.846, 95% confidence interval 1.29,18.3), fewer adverse even
ts, better earning and were more likely to be married than the control grou
p.
Conclusions In patients with adult onset epilepsy, a minimum of two drug es
timations per year offers significant benefit in terms of better seizure co
ntrol, fewer adverse events and greater chances of remission.