Highly efficient deacetylation by use of the neutral organotin catalyst [tBu(2)SnOH(Cl)](2)

Deprotection of acetyl esters is effected cleanly by the neutral organotin catalyst, [tBu(2)SnOH(Cl)](2). The mildness of the reaction gives rise to g reat synthetic versatility and in the process a variety of functional group s are tolerated. Differentiations between primary, secondary, and tertiary alcohols and between acetyl ester and other esters are feasible. No racemiz ation occurs with chiral acetyl esters. Exclusive deprotection of primary a cetyl esters in carbohydrates and nucleosides is observed. The crude produc t thus obtained can be used for further reactions without purification.