Plasma atrial natriuretic peptide (ANP) fragments proANP (1-30) and proANP(31-67) measurements in chronic heart failure: a useful index for heart trasplantation?
E. Cappellin et al., Plasma atrial natriuretic peptide (ANP) fragments proANP (1-30) and proANP(31-67) measurements in chronic heart failure: a useful index for heart trasplantation?, CLIN CHIM A, 310(1), 2001, pp. 49-52
The family of the atrial natriuretic peptides, proANP fragments and the act
ive alpha ANP, is strongly related to heart disease. The aim was to study i
n CHF subjects the relation of mdANP and NtANP with brain natriuretic pepti
de (BNP) and with other traditional medical parameters. Sixteen CHF patient
s (aged 51.9 +/- 13.7 years) and 16 healthy subjects age matched (50.8 +/-5
.9 years) were selected. Both NtANP and mdANP were higher in CHF patients t
han in healthy subjects (1436 +/- 288 vs. 288 +/- 22 pmol/l p<0.001 and 230
5<plus/minus>383 vs. 423 +/- 65 pmol/l p<0.0001, respectively). BNP in CHF
patients was 28.0<plus/minus>9 pmol/l (reference values 1.7 +/-1.8 pmol/l).
Both NtANP and mdANP demonstrated positive correlation with BNP, p<0.0001
and with left atrial end-systolic volume, p<0.05. BNP correlated with left
ventricular mass, p<0.03. In conclusion, plasma NtANP and mdANP analyses ar
e useful laboratory markers in CHF patient investigation and follow up. In
particular, they could be employed as non-invasive parameters to follow up
worsening of systolic dysfunction until heart transplantation is required.
(C) 2001 Elsevier Science BN. All rights reserved.