Trypanosome lytic factors: novel mediators of human innate immunity

Authors
Raper, J Portela, MPM Lugli, E Frevert, U Tomlinson, S
Citation
J. Raper et al., Trypanosome lytic factors: novel mediators of human innate immunity, CURR OPIN M, 4(4), 2001, pp. 402-408
Citations number
55
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
4
Issue
4
Year of publication
2001
Pages
402 - 408
Database
ISI
SICI code
1369-5274(200108)4:4<402:TLFNMO>2.0.ZU;2-1
Abstract
A novel trypanosome lytic factor (TLF) has been characterized that protects humans from infection by Trypanosoma brucei brucei. The mechanism of trypa nolysis is unknown; contrary to one hypothesis, TLF does not kill trypanoso mes by generating oxygen radicals. However, these trypanosomes become human -infective when they express a serum-resistance-associated gene.