Plasmodium telomeres: a pathogen's perspective

Citation
A. Scherf et al., Plasmodium telomeres: a pathogen's perspective, CURR OPIN M, 4(4), 2001, pp. 409-414
Citations number
44
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
4
Issue
4
Year of publication
2001
Pages
409 - 414
Database
ISI
SICI code
1369-5274(200108)4:4<409:PTAPP>2.0.ZU;2-I
Abstract
New data on the organization of plasmodial telomeres has recently become av ailable. Telomeres form clusters of four to seven heterologous chromosome e nds at the nuclear periphery in asexual and sexual parasite stages. This su bnuclear compartment promotes gene conversion between members of subtelomer ic virulence factor genes in heterologous chromosomes resulting in diversit y of antigenic and adhesive phenotypes. This has important implications for parasite survival.