The machinery for flavivirus fusion with host cell membranes

Authors
Heinz, FX Allison, SL
Citation
Fx. Heinz et Sl. Allison, The machinery for flavivirus fusion with host cell membranes, CURR OPIN M, 4(4), 2001, pp. 450-455
Citations number
39
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
4
Issue
4
Year of publication
2001
Pages
450 - 455
Database
ISI
SICI code
1369-5274(200108)4:4<450:TMFFFW>2.0.ZU;2-T
Abstract
A combination of structural, biochemical and functional studies with the fl avivirus tick-borne encephalitis virus has revealed the characteristics of a new class of viral fusion protein, class II, that is unrelated to the cla ss I viral fusion proteins for which influenza virus hernagglutinin is the prototype. New structural data have shown that the alphaviruses, another gr oup of icosahedral enveloped viruses, also have class II fusion proteins, s uggesting a common origin.