Channel-tunnels

Authors
Koronakis, V Andersen, C Hughes, C
Citation
V. Koronakis et al., Channel-tunnels, CURR OP STR, 11(4), 2001, pp. 403-407
Citations number
37
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
403 - 407
Database
ISI
SICI code
0959-440X(200108)11:4<403:C>2.0.ZU;2-A
Abstract
TolC and its many homologues comprise an alpha -helical transperiplasmic tu nnel embedded in the bacterial outer membrane by a contiguous beta -barrel channel, providing a large exit duct for diverse substrates. The 'channel-t unnel' is closed at its periplasmic entrance, but can be opened by an 'iris -like' mechanism when recruited by substrate-engaged proteins in the cytoso lic membrane.