Metalloprotein and redox protein design

Metalloprotein and redox protein design are rapidly advancing toward the ch emical synthesis of novel proteins that have predictable structures and fun ctions. Current data demonstrate a breadth of successful approaches to meta llopeptide and metalloprotein design based on de novo, rational and combina torial strategies. These sophisticated synthetic analogs of natural protein s constructively test our comprehension of metalloprotein structure/functio n relationships. Additionally, designed redox proteins provide novel constr ucts for examining the thermodynamics and kinetics of biological electron t ransfer.