Protective effect of amtolmetin guacyl versus placebo diclofenac and misoprostol in healthy volunteers evaluated as gastric electrical activity in alcohol-induced stomach damage

Amtolmetin guacyl (AMG) is a nonsteroidal antiinflammatory drug (NSAID) of high therapeutic activity and free of damaging effects on the gastrointesti nal tract. Since acute ulcer and nausea have been found to be associated wi th gastric dysrhythmias, cutaneous electrogastrography and ultrasonographic study of the gastric emptying time were performed simultaneously in 24 hea lthy volunteers before and for 180 min after a liquid meal with 0.5 g/kg bo dy weight of alcohol in double-blind, placebo-controlled, crossover studies . Before the recording session, each subject had taken placebo, AMG, a stan dard NSAID, or a gastric protective drug for four days. Alcohol administrat ion increased the tachygastria percentage while diclofenac, AMG, and misopr ostol alone did not induce gastrointestinal symptoms and gastric dysrhythmi as. As regards alcohol-induced gastric dysrhythmia, placebo and diclofenac showed a clear increase in tachygastria while AMG and misoprostol did not. AMG is able to induce a normalization of gastric dysrhythmia induced by alc ohol administration probably due to its peculiar mechanism of action, which involves capsaicin and CGRP pathways.