Compliance with follow-up and prognosis among patients with thin melanomas

The aim of this study was to report on the compliance with follow-up among patients with thin melanomas. We also examined the prognosis of patients wi th recurrent disease and whether there were any differences in prognosis as sociated with the time between the last follow-up examination and the onset of recurrence. A retrospective analysis of the records of 513 consecutive patients (50.3% males, mean age: 52.8 +/- 16.9 years) with thin melanomas ( <1.5 mm Breslow thickness) was carried out. The estimated cumulative propor tion of patients who still continued their follow-up examinations 5 years a fter diagnosis of the primary turnout was 55.3% (95% Confidence Interval (C l): 50.4-60.2%) The mean annual drop-out rate was 11.2%. The drop-out rate was similar for males and females and was not influenced by the patients' a ge or the tumour thickness. Among 263 patients who continued follow-up, 50. 2% (n = 132) were not compliant with the time schedule. 20 patients present ed with recurrent disease after a median of 35.9 months (25-75% percentiles : 16.7-46.5 months). Six patients who did not have a follow-up examination within I year before the onset of recurrence presented with more advanced d isease and had a worse prognosis (median survival: 12.5 months, hazard rati o: 3.5, 95% CI: 1.1-17.1, P = 0.04), than those patients, who had a recent follow-up examination before the onset of recurrence (n = 14, median surviv al: 22.3 + months). In the majority of recurrent cases with good prognosis, metastatic disease was confined to the regional lymph nodes and the presum ptive diagnosis of metastatic disease was either made by palpation or by so nography of the regional lymph nodes. The observed drop-out rate of patient s during the first 5 years of follow-up is substantial and does not depend on the patients' age, sex or on the tumour thickness. Although the frequenc y of recurrences among patients with thin melanomas is low, regular follow- up examinations including physical examination, as well as palpation and so nography of the regional lymph nodes, are essential. (C) 2001 Elsevier Scie nce Ltd. All rights reserved.