Citation
A. Krause et al., Human natriuretic peptides exhibit antimicrobial activity, EUR J MED R, 6(5), 2001, pp. 215-218
Citations number
18
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
EUROPEAN JOURNAL OF MEDICAL RESEARCH
ISSN journal
09492321
→ ACNP
Volume
6
Issue
5
Year of publication
2001
Pages
215 - 218
Database
ISI
SICI code
0949-2321(20010529)6:5<215:HNPEAA>2.0.ZU;2-2
Abstract
Here we describe a novel function for members of the well-characterized hum
an natriuretic peptide family. Human "brain-type natriuretic peptide" (hBNP
-32) as well as other members of this peptide class are antimicrobially act
ive against Gram-positive and Gram-negative bacteria and yeast in a dose-de
pendent manner. This activity of natriuretic-peptides is comparable to that
of known antimicrobial peptides such as casocidins or magainins.