Role of gamma delta T-lymphocytes in HIV infection

T-lymphocytes expressing the gamma delta T-cell receptor (TCR) comprise a s mall proportion (1-5%) of circulating CD3+ T-lymphocytes. While T-cells exp ressing a V delta 2V gamma9-encoded TCR dominate among peripheral blood gam ma delta T-lymphocytes in healthy individuals, significant alternation in t he gamma delta TCR repertoire are observed in HIV-infected persons. These c hanges are due to the selective preservation (and frequently moderate expan sion) of V delta1-expressing cells and the simultaneous depletion of V delt a2-expressing cells. In this brief review, we discuss the alterations in th e gamma delta T-lymphocyte compartment in HIV infection, with special empha sis on the potential role of gamma delta T-cell in the immune defense again st HIV.