Gd. Georgeson et al., Natural killer cell cytotoxicity is deficient in newborns with sepsis and recurrent infections, EUR J PED, 160(8), 2001, pp. 478-482
We investigated natural killer (NK) cell cytotoxicity in healthy preterm an
d full-term newborns in comparison to adults, to elucidate the possible rol
e of delivery mode in influencing the NK activity and to evaluate the NK ac
tivity in severe neonatal pathological conditions such as bacterial sepsis
and recurrent infections. NK cell cytotoxicity was investigated using a 4 h
Cr-51 release assay with K562 cells as targets expressed as percentage kil
l in the following study groups: full-term normal spontaneous vaginal deliv
ery (n = 55), full-term caesarean section (n = 51), preterm normal spontane
ous vaginal delivery (n = 34), preterm caesarean section (n = 28), bacteria
l sepsis (n = 15), recurrent neonatal infections (n = 8) and healthy adults
aged between 22-42 years (n = 89). NK activity for the normal newborns was
determined in paired cord and 2-4 day-old neonate blood. The NK cell cytot
oxicity in healthy newborns was significantly lower than in adults (P < 0.0
1). Prematurity was associated with a significant decrease in NK cell activ
ity compared to full-term neonates (P < 0.05). The mode of delivery did not
influence the NK cytotoxicity. In sepsis and recurrent infections, a drama
tic decrease in NK cell cytotoxicity was seen related to healthy newborns (
P < 0.01).
Conclusion Natural killer cell cytotoxicity is deficient in both neonatal s
epsis and recurrent infections.