EFFECT OF PULSED MAGNETIC-FIELDS ON THE CYTOTOXICITY OF MICE PERITONEAL-MACROPHAGES

The cytotoxicity of mice peritoneal macrophages was studied in vitro i n order to look for a change in their functional activity when they we re exposed to pulsed magnetic fields (PMF) such as those used in thera py. The macrophages were exposed for 1 h to a 12 Hz or a 460 Hz 6 mT P FM and then put in a suspension of labeled EL4 cells. The cytotoxicity was increased for the 1/200 concentration of the target cells relativ e to the macrophages. But in seven experiments that took place over 8 months, the increase of cytotoxicity was significant only three times. This fact suggests a temporal change in the cell sensitivity to PMF.