Portal vein thrombosis associated with a myeloproliferative disorder, prothrombin G20210A mutation, antiphospholipid syndrome, with repermeation during anticoagulant therapy

Portal vein thrombosis, except in hepatocellular carcinoma and severe cirrh osis, is due to one or several prothrombotic disorders with or without a lo cal precipitating factor. We report a case of a portal and splenic vein thr ombosis, without cavernoma and varices which occurred in a 72-year-old man with abdominal pain and weakness. Three prothrombotic states including late nt myeloproliferative disorder, antiphospholipid syndrome, and factor II G2 02101 mutation, were observed. Anticoagulant treatment resulted in complete repermeation of the portal and splenic veins without a hemorrhagic event. This illustrates that several prothrombotic states may occur in a single pa tient with portal vein thrombosis. Early anticoagulant therapy, in recent p ortal vein thrombosis, can result in repermeation.