Hysteroscopic and immunohistochemical findings in endometrial lesions unresponsive to medroxyprogesterone acetate: a report on four cases

Objective This is a case report showing an association between c-erbB2 over -expression in the endometrium and lack of response to progesterone. Patients and methods Determinations of oestrogen and progesterone receptors by immunohistochemistry were carried out in four patients with endometrial lesions that did not respond to the administration of progestins, and resu lts were correlated with the presence of c-erbB2 over-expression. Results The presence of c-erbB2 over-expression in the endometrium was asso ciated with a lack of response to progesterone even in the presence of rece ptors for this hormone. Conclusion The presence of c-erbB2 over-expression in the endometrium may b e an early event in the development of some forms of atypical complex hyper plasia or carcinoma that may not regress with progesterone treatment.