A limited sampling strategy for cyclosporine area under the curve monitoring in lung transplant recipients

We developed a limited sampling strategy (LSS) for predicting cyclosporine (Neoral) area under the curve from concentration-time data obtained specifi cally from lung transplant recipients. The optimal and most clinically conv enient LSS for lung transplant recipients, based on patient wait time, numb er of blood samples required, percent prediction error, and assessment of p redictive performance is one that requires 2 blood samples collected at 1 a nd 3 hours post-dose: AUC = 1.75 x C-1 + 4.91 x C-3 + 185.62.