Prospective surveillance of hospital-acquired infections was undertake
n in the geriatric ward of the University Hospital, Utrecht, the Nethe
rlands. The medical records of 300 patients mere studied for the prese
nce of nosocomial infections using the criteria defined by the Centers
for Disease Control (CDC), Atlanta, Georgia, USA. Data were collected
from patients with and without infection, which allowed for the analy
sis of risk factors for nosocomial infection. In 100 out of 300 patien
ts (33.3%), a total of 126 infections was diagnosed. The incidence of
nosocomial infections was 16.9 per 1000 days of stay in the hospital.
The mean length of stay of patients with infection was 39 days, while
that of patients without infection was 17.8 days. Infections developed
after an average stay of 13.3 days in the hospital. Patients with inf
ections were 2.6 years older than patients without infections (P=0.005
). Dehydration was shown to be a major risk factor for infection (RR =
2.1, 95% CI: 1.4-3.2). Of the infections, 58.7% were urinary tract in
fections (UTIs, asymptomatic and symptomatic). The most important risk
factor for an asymptomatic UTI was an indwelling urinary catheter (RR
= 7.3, 95% CI: 3.1-17.1). The duration of use of the indwelling urina
ry catheter was of significant influence in the development of a UTI.
Seventy percent of the patients with an asymptomatic UTI were treated
with antibiotics. Infections of the gastrointestinal tract accounted f
or 19.8% of all nosocomial infections. The majority of these infection
s were due to an outbreak of Clostridium difficile. In conclusion, the
length of stay may be prolonged by a nosocomial infection. In this st
udy, the main risk factors for developing a nosocomial infection were
age, dehydration and the presence of an urinary catheter. Our observat
ions showed that age is a predisposing factor for nosocomial infection
and that the risk increases with each year, even for geriatric patien
ts.