DOSE PROPORTIONALITY OF CISATRACURIUM

Citation
Vd. Schmith et al., DOSE PROPORTIONALITY OF CISATRACURIUM, Journal of clinical pharmacology, 37(7), 1997, pp. 625-629
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00912700
Volume
37
Issue
7
Year of publication
1997
Pages
625 - 629
Database
ISI
SICI code
0091-2700(1997)37:7<625:DPOC>2.0.ZU;2-G
Abstract
The dose proportionality of cisatracurium pharmacokinetics was assesse d using a population approach by incorporating the collection of spars e blood samples from patients in clinical trials. Plasma concentration -time data from 131 patients with limited concentration-time data and 38 patients with full sampling were pooled and analyzed using nonlinea r mixed-effects modeling (NONMEM). Dose proportionality was assessed u sing dichotomous parameterization and a linear model. The population p harmacokinetic approach revealed that the pharmacokinetics of cisatrac urium are independent of dose between 0.1 mg/kg and 0.4 mg/kg, as was expected based on the importance of Hofmann elimination, a chemical pr ocess dependent on pH and temperature.