Superior vena cava (SVC) syndrome is a disabling and potentially life-threa
tening complication. SVC revascularization can be achieved by means of endo
vascular or direct surgical reconstructions. In the patient on whom we repo
rt, these two options were not possible, and a peripheral venous bypass gra
fting procedure was done with a technical innovation. Right upper-extremity
swelling developed in a 55-year-old woman after radiation therapy for lung
carcinoma. A left subclavian vein Port-A-Cath induced extensive thrombosis
of the left innominate, axillosubclavian, and jugular veins. She was refer
red to our institution with very symptomatic SVC syndrome after two failed
endovascular interventions. The occlusion of both innominate veins and chro
nic thrombus extending into the left axillosubclavian and internal jugular
veins was confirmed by means of a venogram. A third endovascular attempt fa
iled. The presternal skin had severe radiation-induced damage precluding di
rect SVC reconstruction. A bypass grafting procedure from the right interna
l jugular to the femoral vein was performed with spliced bilateral greater
saphenous veins tunneled inside an externally supported expanded polytetraf
luoroethylene graft. Postoperatively, the patient had no symptoms, and graf
t patency was confirmed by means of duplex ultrasound scanning. A saphenoju
gular bypass grafting procedure ran offer prompt and durable relief of SVC
syndrome when endovascular or direct surgical reconstructions are not possi
ble. This rarely used peripheral venous bypass grafting procedure was modif
ied by tunneling the vein graft inside an externally supported poly tetrafl
uoroethylene graft to prevent kinking or compression.