Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein
E. De Rosny et al., Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein, J VIROLOGY, 75(18), 2001, pp. 8859-8863
Two heptad repeat regions in the ectodomain of the human immunodeficiency v
irus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-h
elix bundle structure that is critical for virus entry. Immunizations with
peptides corresponding to these regions generated antibodies specific to th
e receptor-activated conformations of gp41.