Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein

Authors
De Rosny, E Vassell, R Wingfield, PT Wild, CT Weiss, CD
Citation
E. De Rosny et al., Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein, J VIROLOGY, 75(18), 2001, pp. 8859-8863
Citations number
18
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
18
Year of publication
2001
Pages
8859 - 8863
Database
ISI
SICI code
0022-538X(200109)75:18<8859:PCTTHR>2.0.ZU;2-A
Abstract
Two heptad repeat regions in the ectodomain of the human immunodeficiency v irus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-h elix bundle structure that is critical for virus entry. Immunizations with peptides corresponding to these regions generated antibodies specific to th e receptor-activated conformations of gp41.