Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors

Authors
Brady, CA Stanford, IM Ali, I Lin, L Williams, JM Dubin, AE Hope, AG Barnes, NM
Citation
Ca. Brady et al., Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors, NEUROPHARM, 41(2), 2001, pp. 282-284
Citations number
10
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPHARMACOLOGY
ISSN journal
00283908 → ACNP
Volume
41
Issue
2
Year of publication
2001
Pages
282 - 284
Database
ISI
SICI code
0028-3908(200108)41:2<282:PCOHH5>2.0.ZU;2-W
Abstract
The present study determined the detailed pharmacological profile of hetero logously expressed human (h) homomeric 5-HT3A receptors in direct compariso n to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subu nit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.