Fructose-1,6-bisphosphate did not affect hippocampal neuronal damage caused by 10 min of complete umbilical cord occlusion in fetal sheep

Fructose-1, 6-bisphosphate (FBP) has a neuroprotective effect in neonatal a nd adult rats. The purpose of this study was to examine the effects of FBP on hippocampal neuronal damage in fetal sheep asphyxiated by 10 min of comp lete umbilical cord occlusion. Thirteen fetal sheep at 124 days of gestatio n were surgically instrumented with catheters. Cardiorespiratory parameters were monitored, and biochemical analyses were performed with the blood sam ples. During the insult seven fetuses were given FBP (500 mg/kg) and six we re given iso-osmotic saline, and hippocampal neuronal damage was examined h istologically and scored. Cardiorespiratory changes were the same in both g roups, and there was no neuroprotective effect of FBP in this study. Howeve r the decrease of serum total Ca level implied the Ca-chelating effect of F BP. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.