Pl. Mendez et al., Chronic amphetamine administration decreases D-2 dopamine receptor immunostaining in the lateral habenular nucleus, NEUROSC R C, 29(1), 2001, pp. 59-68
The effect of chronic amphetamine administration on the expression of D-2 d
opamine receptor was immunohistochemically analyzed in the caudate-putamen
and the lateral habenular nucleus, which are important links of the dorsal
diencephalic conduction system. Significant decrease in the numbers of immu
nopositive neural cells was observed in both regions, suggesting that chron
ically administered amphetamine alters D-2 dopamine receptor function in th
e dorsal diencephalic conduction system. This could be involved in the deve
lopment of schizophrenia, stereotypies and neural impairment in psychostimu
lant abusers.