PROLONGED ORAL ETOPOSIDE FOR ADVANCED UTERINE LEIOMYOSARCOMA WITH PULMONARY METASTASES - CASE-REPORT

A patient who had a high grade uterine leiomyosarcoma with intraabdomi nal and pulmonary metastases at the time of diagnosis underwent suprac ervical hysterectomy, bilateral salpingo-oophorectomy and tumor reduct ive surgery. Induction chemotherapy achieved a partial response with s mall amount of residual disease. On achieving a plateau in the respons e to her induction chemotherapy, she was switched to prolonged oral et oposide at a dose of 50 mg/m(2)/day 21 days with a 7-day rest period b etween cycles. Follow up imaging revealed stable disease with a slight decrease in the size of the paraaortic lymphnodes. Prolonged oral eto poside may be considered in patients with advanced high grade leiomyos arcoma of the uterus.