VULVAR-DYSTROPHY - AN EVALUATION OF 285 CASES

To determine the effectiveness of medical therapy in vulvar dystrophy, a retrospective, single-institute clinicopathologic study of 285 cons ecutive cases was carried out. Of the patients, 152 (53.3%) had squamo us hyperplasia (SH), 72 (25.3%) had lichen sclerosus (LS), and 61 (21. 4%) had lichen sclerosus with areas of squamous hyperplasia (LS+SH). S ymptomatic response was 84.8% at 3 months and 92.7% at 6 months in pat ients with SH. These figures were 70.8% and 87.5% for patients with LS and 68.8% and 80.3% for patients with SH+LS, respectively. Histopatho logical response was 63.6% at 3 months and 74.8% at 6 months for patie nts with SH. These figures were approximately 29% and 42% for LS, and 21% and 34% for patients with SH+LS, respectively. Corticosteroids for squamous hyperplasia and testosterone for lichen sclerosus achieved a high symptomatic response. However, histologic remission rates were p oorer.