Hepatitis A virus infection is usually a self-limited disease during childh
ood. Autoimmune manifestations are rarely reported among patients. We descr
ibe two children with acute hepatitis A infection who developed immune thro
mbocytopenia and hepatic venous thrombosis during the course of acute infec
tion. Antiphospholipid antibodies were increased in both of them during the
thrombocytopenic and thrombotic complications and decreased during the res
olution of these events.