Antituberculosis agents, I: Synthesis and antituberculosis activity of 2-aryl-1,3,4-thiadiazole derivatives

Authors
Foroumadi, A Mirzaei, M Shafiee, A
Citation
A. Foroumadi et al., Antituberculosis agents, I: Synthesis and antituberculosis activity of 2-aryl-1,3,4-thiadiazole derivatives, PHARMAZIE, 56(8), 2001, pp. 610-612
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
56
Issue
8
Year of publication
2001
Pages
610 - 612
Database
ISI
SICI code
0031-7144(200108)56:8<610:AAISAA>2.0.ZU;2-V
Abstract
The design, synthesis and antituberculosis activity of a series of 2-aryl-5 -methylthio-1,3,4-thiadiazoles (5a-b), ethyl alpha-(5-aryl)-1,3,4-thiadiazo le-2-ylthio)acetates (8a-b) and related compounds are described. All of the compounds were tested against Mycobacterium tuberculosis strain H37Rv in c omparison to rifampicin. Six compounds exhibited a very good activity (MIC < 6.25 mug/ml, % Inhibition = 100).